Hinokiflavone is a novel CK2 inhibitor promoting apoptosis and synergizing with chemotherapeutic agents in cisplatin resistant bladder cancer cells

Abstract Bladder cancer (BC) remains a major therapeutic challenge, particularly in patients with acquired resistance to platinum-based chemotherapy. In this study, we investigated the potential of hinokiflavone (HNK), a natural biflavonoid, as a therapeutic agent against cisplatin-resistant BC. Our...

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Bibliographic Details
Main Authors: Tsung-Han Hsieh, Han-Pin Kuo, Mei-Chuan Chen, Yu-Chen Lin, Bo-Jyun Lin, Kai-Cheng Hsu, Chun-Han Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-06543-3
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