BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling

BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling

Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder presenting with progressive heterotopic ossification (HO) in soft tissues. Early-stage FOP is characterized by recurrent episodes of painful tissue swelling (flare-ups), with numerous proliferation-activated mesenchymal...

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Bibliographic Details
Main Authors: Chengzhu Zhao, Yoshiko Inada, Souta Motoike, Daisuke Kamiya, Kyosuke Hino, Makoto Ikeya
Format: Article
Language:English
Published: Springer Nature 2024-12-01
Series:EMBO Molecular Medicine
Subjects:
Fibrodysplasia Ossificans Progressive
Flare-Up
Fibroproliferation
Patient-Derived Induced Pluripotent Stem Cells
TGF-β Signaling
Online Access:https://doi.org/10.1038/s44321-024-00174-3
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https://doi.org/10.1038/s44321-024-00174-3

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