DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization

DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization

Abstract Dentin sialophosprotein (DSPP) is cleaved into the N-terminal dentin sialoprotein (DSP) proteoglycan and the C-terminal dentin phosphoprotein (DPP; the most acidic proteins in humans). To define the functions of DSP and DPP, we generated a Dspp −DPP mouse model using CRISPR/Cas9 technology...

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Bibliographic Details
Main Authors: Tian Liang, Charles E. Smith, Yuanyuan Hu, Hong Zhang, Chuhua Zhang, James P. Simmer, Jan C.-C. Hu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Dentin Sialophosphoprotein
Dentin sialoprotein
Dentin phosphoprotein
Dentin
Dentin mineralization
Biomineralization
Online Access:https://doi.org/10.1038/s41598-025-09743-z
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https://doi.org/10.1038/s41598-025-09743-z

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