Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT

Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT

Background Procalcitonin is a biomarker specific for bacterial infection, with a more rapid response than other commonly used biomarkers, such as C-reactive protein, but it is not routinely used in the National Health Service. Objective To determine if using a procalcitonin-guided algorithm may safe...

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Main Authors: Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol
Format: Article
Language:English
Published: NIHR Journals Library 2025-05-01
Series:Health Technology Assessment
Subjects:
bacterial infection
paediatrics
hospitalisation
secondary care
antibiotic duration
biomarker
procalcitonin
cost-effectiveness
quality of life
randomised controlled trial
Online Access:https://doi.org/10.3310/MBVA3675
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https://doi.org/10.3310/MBVA3675

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