MDM2 amplification in a real-world cohort of patients with biliary tract cancer from the Spanish RETUD gastrointestinal registry

MDM2 amplification in a real-world cohort of patients with biliary tract cancer from the Spanish RETUD gastrointestinal registry

Background: Antagonist of mouse double minute 2 homolog (MDM2) represents a novel therapeutic strategy in biliary tract cancer (BTC). We aimed to characterize the epidemiology of MDM2 amplifications in patients with BTC, associations of MDM2 with other genetic alterations, and survival outcomes. Mat...

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Main Authors: A.J. Muñoz Martín, F. Castet, J. Soto Alsar, J. Adeva, P. Peinado, B. Graña, I. Alés Díaz, R.M. Rodríguez-Alonso, M. Lobo de Mena, R. Vera, I. Ruiz de Mena, S. Aguilar, S. Vega, L. Ortega Morán, T. Macarulla
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:ESMO Gastrointestinal Oncology
Subjects:
MDM2 amplification
biliary tract cancer
RETUD registry
real-world data
Spain
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819825000561
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