Mitochondria-targeted antioxidant MitoQ radiosensitizes tumors by decreasing mitochondrial oxygen consumption

Mitochondria-targeted antioxidant MitoQ radiosensitizes tumors by decreasing mitochondrial oxygen consumption

Abstract Hypoxic tumors are radioresistant stemming from the fact that oxygen promotes reactive oxygen species (ROS) propagation after water radiolysis and stabilizes irradiation-induced DNA damage. Therefore, an attractive strategy to radiosensitize solid tumors is to increase tumor oxygenation at...

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Main Authors: Justin D. Rondeau, Sara Lipari, Barbara Mathieu, Claire Beckers, Justine A. Van de Velde, Lionel Mignion, Mauricio Da Silva Morais, Marvin Kreuzer, Ilaria Colauzzi, Tania Capeloa, Martin Pruschy, Bernard Gallez, Pierre Sonveaux
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02277-9
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https://doi.org/10.1038/s41420-024-02277-9

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