TSPAN15 sustains ITGB1 stability to block gemcitabine-induced ferroptosis in pancreatic ductal adenocarcinoma through the FAK/AKT/Mtor-gpx4 cascade

TSPAN15 sustains ITGB1 stability to block gemcitabine-induced ferroptosis in pancreatic ductal adenocarcinoma through the FAK/AKT/Mtor-gpx4 cascade

Chemotherapy remains a pivotal strategy in the treatment of pancreatic ductal adenocarcinoma (PDAC). Nonetheless, the emergence of drug resistance has limited the clinical efficacy of chemotherapeutic agents, especially gemcitabine. Here, we identified tetraspanin-15 (TSPAN15), a member of the tetra...

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Bibliographic Details
Main Authors: Peng Nan, Xiao Wang, Anan Li, Yumei Ge, Zongting Gu, Yingying Wang, Ran Tao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Pancreatic ductal adenocarcinoma
Tetraspanin-15
Gemcitabine
Chemoresistance
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002344
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