The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients

The common genetic variant rs1278960 determining expression of Interferon-lambda predicts inflammatory response in critically ill COVID-19 patients

Abstract The single nucleotide polymorphism rs12979860 is associated with the production of IFNλ4, a type III interferon, which offers protection from viral infection via its proinflammatory properties. We investigated if a genetically determined increase in IFNλ4 affects disease progression in SARS...

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Main Authors: Timo Mayerhöfer, Michael Joannidis, Sebastian Klein, Andre Franke, Sara Margarita, Luisa Ronzoni, Elke Pertler, Sonja Wagner, Sabina Sahanic, Ivan Tancevski, David Haschka, Christoph Hochhold, Benedikt Treml, Luca Valenti, Herbert Tilg, Benedikt Schaefer, Heinz Zoller
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
Ferritin
Neopterin
Immune response
Interferon lambda 4
Interleukin 28B
Online Access:https://doi.org/10.1038/s41598-025-91628-2
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https://doi.org/10.1038/s41598-025-91628-2

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