Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives HIV persistence in lymph node B cell follicles

Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives HIV persistence in lymph node B cell follicles

Summary: B cell follicles (BCFs) in the lymph node are a major sanctuary for HIV reservoirs. Immune regulatory mechanisms hindering cytolytic CD8+ responses at these sites are poorly characterized, likely enabling HIV persistence. Spatial transcriptomics and high-dimensional histocytometry were used...

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Main Authors: Andrea O. Papadopoulos, Leonard Mvaya, Trevor Khaba, Namani Ngema, Werner Smidt, Sibongiseni Msipa, Bongiwe Mahlobo, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw, Kondwani Jambo, Zaza Ndhlovu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009520
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