Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells

Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells

Respiratory infections caused by Bordetella pertussis are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating B. pertussis strains increasingly lack expression of the vaccine component pertactin...

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Bibliographic Details
Main Authors: Michiel M. Kroes, Alberto Miranda-Bedate, Elise S. Hovingh, Ronald Jacobi, Corrie Schot, Elder Pupo, René H. M. Raeven, Arno A. J. van der Ark, Jos P. M. van Putten, Jelle de Wit, Rob Mariman, Elena Pinelli
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Emerging Microbes and Infections
Subjects:
Pathogen adaptation
pertactin
dendritic cell
transcriptomics
RNAseq
proteomics
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2021.1943537
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https://www.tandfonline.com/doi/10.1080/22221751.2021.1943537

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