NAD+/Nrf2 signaling promotes osteogenesis by regulating oxidative level of BMSCs under mechanical stress

NAD+/Nrf2 signaling promotes osteogenesis by regulating oxidative level of BMSCs under mechanical stress

Abstract Background Mechanical stress triggers an increase in cellular reactive oxygen species (ROS), which is associated with the impairment of osteogenesis. During orthodontic treatment, bone marrow mesenchymal stem cells (BMSCs) experience mechanical stress, yet the oxidative profile and redox re...

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Bibliographic Details
Main Authors: Huiying Ren, Jixiao Wang, Jiani Liu, Zijie Zhang, Lingyun Wang, Fulan Wei
Format: Article
Language:English
Published: SpringerOpen 2025-05-01
Series:Progress in Orthodontics
Subjects:
Mechanical stress
Bone marrow mesenchymal stem cells
Oxidative homeostasis
NAD+
Nrf2
Osteogenic commitment
Online Access:https://doi.org/10.1186/s40510-025-00566-2
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https://doi.org/10.1186/s40510-025-00566-2

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