Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer

Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer

Abstract The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold function largely involves the interaction between FAK’s focal adhesion targeting (FAT) domain and paxillin, ultimatel...

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Main Authors: Lauren Reyes, Lena Naser, Warren S. Weiner, Darren Thifault, Erik Stahl, Liam McCreary, Rohini Nott, Colton Quick, Alex Buchberger, Carlos Alvarado, Andrew Rivera, Joseph A. Miller, Ruchi Khatiwala, Brian R. Cherry, Ronald Nelson, Jose M. Martin-Garcia, Nicholas Stephanopoulos, Raimund Fromme, Petra Fromme, William Cance, Timothy Marlowe
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57196-9
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https://doi.org/10.1038/s41467-025-57196-9

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