Culicoides allergens expressed in insect cells induce sulphidoleukotriene release from peripheral blood leukocytes of horses affected with insect bite hypersensitivity

Culicoides allergens expressed in insect cells induce sulphidoleukotriene release from peripheral blood leukocytes of horses affected with insect bite hypersensitivity

IntroductionInsect bite hypersensitivity (IBH) is an IgE-mediated dermatitis in horses caused by bites of Culicoides spp. The allergens are salivary gland proteins from these insects, and nine major allergens from Culicoides obsoletus have been identified and expressed in E. coli. However, proteins...

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Bibliographic Details
Main Authors: Sigridur Jonsdottir, Sara Björk Stefansdottir, Jelena Mirkovitch, Anja Ziegler, Sigurbjörg Torsteinsdottir, Eliane Marti
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
horse
insect bite hypersensitivity
Culicoides allergens
insect cell expressed recombinant proteins
sulphidoleukotriene release
serum IgE
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597233/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1597233/full

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