Allelic variation in a cluster of epsilon glutathione S-transferase genes contributes to DDT and pyrethroid resistance in the major African malaria vector Anopheles funestus

Allelic variation in a cluster of epsilon glutathione S-transferase genes contributes to DDT and pyrethroid resistance in the major African malaria vector Anopheles funestus

Abstract Background Insecticide resistance in malaria vectors is a serious challenge to malaria control and elimination. Elucidation of the role of detoxification genes in resistance is necessary to develop targeted strategies to reduce malaria burden. Glutathione S-transferase epsilon clusters (GST...

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Main Authors: Mersimine F. M. Kouamo, Sulaiman S. Ibrahim, Abdullahi Muhammad, Mahamat Gadji, Jack Hearn, Charles S. Wondji
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Genomics
Subjects:
Malaria
Anopheles funestus
pyrethroids/DDT
Metabolic resistance
Glutathione S-transferase
Transgenic expression, metabolic assay
Online Access:https://doi.org/10.1186/s12864-025-11637-3
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https://doi.org/10.1186/s12864-025-11637-3

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