Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome

Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome

Abstract Background Glucocorticoid (GC) response heterogeneity has been recognized as an unfavorable prognostic factor, yet the underlying mechanism remains elusive. In this study, we endeavored to investigate the potential causes from an epigenetic perspective. Methods The protein expression levels...

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Bibliographic Details
Main Authors: Yu heng Liang, Can Liang, Jin Cheng, Qianqian Peng, Ping Zeng, Fengjun Guan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Italian Journal of Pediatrics
Subjects:
Primary nephrotic syndrome
Glucocorticoid receptor
Acetylation
Histone3
Histone4
Nuclear factor-κB
Online Access:https://doi.org/10.1186/s13052-025-01914-y
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https://doi.org/10.1186/s13052-025-01914-y

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