The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer

Abstract Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form of cell death that is crucial for tumo...

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Bibliographic Details
Main Authors: Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le, Yating Dian, Furong Zeng, Xiang Chen, Guangtong Deng
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02192-0
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