Risk profiling for cirrhosis and hepatocellular carcinoma in HFE hemochromatosis using mobilizable iron stores and alcohol consumption

Risk profiling for cirrhosis and hepatocellular carcinoma in HFE hemochromatosis using mobilizable iron stores and alcohol consumption

Abstract HFE hemochromatosis (HH) may cause cirrhosis and hepatocellular carcinoma (HCC). Progression to these endpoints depends on the severity of iron overload and cofactors, such as alcohol. We evaluated alcohol and iron-related risk factors in relation to cirrhosis at diagnosis and future develo...

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Bibliographic Details
Main Authors: Natasha D. P. Mitchell, Timothy G. St Pierre, Louise E. Ramm, Grant A. Ramm, John K. Olynyk
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Hepatocellular carcinoma (HCC)
HFE hemochromatosis (HH)
Hepatic iron concentration (HIC)
Hepatic iron index (HII)
Mobilizable iron (MobFe)
Online Access:https://doi.org/10.1038/s41598-025-99672-8
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https://doi.org/10.1038/s41598-025-99672-8

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