Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity

Abstract Mitochondrial fusion/fission dynamics plays a fundamental role in neuroprotection; however, there is still a severe lack of therapeutic targets for this biological process. Here, we found that the naturally derived small molecule echinacoside (ECH) significantly promotes mitochondrial fusio...

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Main Authors: Ke-Wu Zeng, Jing-Kang Wang, Li-Chao Wang, Qiang Guo, Ting-Ting Liu, Fu-Jiang Wang, Na Feng, Xiao-Wen Zhang, Li-Xi Liao, Mei-Mei Zhao, Dan Liu, Yong Jiang, Pengfei Tu
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-020-00447-6
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https://doi.org/10.1038/s41392-020-00447-6

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