Thonningianin A disrupts pA104R−DNA binding and inhibits African swine fever virus replication

Thonningianin A disrupts pA104R−DNA binding and inhibits African swine fever virus replication

African swine fever is a highly lethal disease caused by the African swine fever virus (ASFV), posing a significant threat to the global pig industry, wherease no approved treatments are currently available. The ASFV DNA-binding protein, pA104R, plays a critical role in viral genome packaging and re...

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Bibliographic Details
Main Authors: Quan-jie Li, Hui-han Shao, Lin-lin Zheng, Qian Liu, Chen-chao Huo, Dong-rong Yi, Tao Feng, Shan Cen
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
pA104R
thonningianin A
DNA-binding protein
ASFV
EMSA
structure-based virtual screening
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2482697
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2482697

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