Viruses Seen by Our Cells: The Role of Viral RNA Sensors
The role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. Different receptors, known as pattern recognition receptors (PRRs), are present in the cytoplasm, endosomes, and on the cellular surface. These receptors h...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/9480497 |
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| _version_ | 1832564756301479936 |
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| author | Elias A. Said Nicolas Tremblay Mohammed S. Al-Balushi Ali A. Al-Jabri Daniel Lamarre |
| author_facet | Elias A. Said Nicolas Tremblay Mohammed S. Al-Balushi Ali A. Al-Jabri Daniel Lamarre |
| author_sort | Elias A. Said |
| collection | DOAJ |
| description | The role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. Different receptors, known as pattern recognition receptors (PRRs), are present in the cytoplasm, endosomes, and on the cellular surface. These receptors have the capacity to sense the presence of viral nucleic acids as pathogen-associated molecular patterns (PAMPs). This recognition leads to the induction of type 1 interferons (IFNs) as well as inflammatory cytokines and chemokines. In this review, we provide an overview of the significant involvement of cellular RNA helicases and Toll-like receptors (TLRs) 3, 7, and 8 in antiviral immune defenses. |
| format | Article |
| id | doaj-art-72a677d2f9d6479ba2d2a43e9c23094b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-72a677d2f9d6479ba2d2a43e9c23094b2025-02-03T01:10:17ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/94804979480497Viruses Seen by Our Cells: The Role of Viral RNA SensorsElias A. Said0Nicolas Tremblay1Mohammed S. Al-Balushi2Ali A. Al-Jabri3Daniel Lamarre4Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, 123 Muscat, OmanCentre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, QC, CanadaDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, 123 Muscat, OmanDepartment of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, 123 Muscat, OmanCentre de Recherche du CHUM (CRCHUM) et Faculté de Médecine, Université de Montréal, Montréal, QC, CanadaThe role of the innate immune response in detecting RNA viruses is crucial for the establishment of proper inflammatory and antiviral responses. Different receptors, known as pattern recognition receptors (PRRs), are present in the cytoplasm, endosomes, and on the cellular surface. These receptors have the capacity to sense the presence of viral nucleic acids as pathogen-associated molecular patterns (PAMPs). This recognition leads to the induction of type 1 interferons (IFNs) as well as inflammatory cytokines and chemokines. In this review, we provide an overview of the significant involvement of cellular RNA helicases and Toll-like receptors (TLRs) 3, 7, and 8 in antiviral immune defenses.http://dx.doi.org/10.1155/2018/9480497 |
| spellingShingle | Elias A. Said Nicolas Tremblay Mohammed S. Al-Balushi Ali A. Al-Jabri Daniel Lamarre Viruses Seen by Our Cells: The Role of Viral RNA Sensors Journal of Immunology Research |
| title | Viruses Seen by Our Cells: The Role of Viral RNA Sensors |
| title_full | Viruses Seen by Our Cells: The Role of Viral RNA Sensors |
| title_fullStr | Viruses Seen by Our Cells: The Role of Viral RNA Sensors |
| title_full_unstemmed | Viruses Seen by Our Cells: The Role of Viral RNA Sensors |
| title_short | Viruses Seen by Our Cells: The Role of Viral RNA Sensors |
| title_sort | viruses seen by our cells the role of viral rna sensors |
| url | http://dx.doi.org/10.1155/2018/9480497 |
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