Blasting neuroblastoma using optimal control of chemotherapy
A mathematical model is used to investigate the effectiveness of thechemotherapy drug Topotecan against neuroblastoma. Optimal control theoryis applied to minimize the tumor volume and the amount of drug utilized.The model incorporates a state constraint that requires the level ofcirculating neutrop...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2009-05-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.451 |
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