Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

Abstract The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution within the Omicron lineage raised concerns of potential...

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Main Authors: Arthur Wickenhagen, Meaghan Flagg, Julia R. Port, Claude Kwe Yinda, Kerry Goldin, Shane Gallogly, Jonathan E. Schulz, Tessa Lutterman, Brandi N. Williamson, Franziska Kaiser, Reshma K. Mukesh, Sarah van Tol, Brian Smith, Neeltje van Doremalen, Colin A. Russell, Emmie de Wit, Vincent J. Munster
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55938-3
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