Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats

Abstract Sodium dehydroacetate (DHA-Na), a widely used preservative, can induce sex-differentiated coagulation disorders primarily resulting from its metabolism. However, the underlying mechanisms remain poorly understood. Here, we identified several Cytochrome P450 (CYP450) sub-enzymes involved in...

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Bibliographic Details
Main Authors: Meng Zhang, Pengfei Du, Yirong Xiao, Hao Liu, Meixue Wang, Yumei Zhang, Xin Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Science of Food
Online Access:https://doi.org/10.1038/s41538-024-00361-z
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