Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice

Glucagon-like peptide-2 pharmacotherapy activates hepatic Farnesoid X receptor-signaling to attenuate resection-associated bile acid loss in mice

Objective: Villus growth in the small bowel by Glucagon-like peptide-2 (GLP-2) pharmacotherapy improves intestinal absorption capacity and is now used clinically for the treatment of short bowel syndrome and intestinal failure occurring after extensive intestinal resection. Another recently acknowle...

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Main Authors: Johannes Reiner, Nooshin Mohebali, Jens Kurth, Maria Witte, Cornelia Prehn, Tobias Lindner, Peggy Berlin, Nagi Elleisy, Robert H. Förster, Alexander Cecil, Robert Jaster, Jerzy Adamski, Sarah M. Schwarzenböck, Brigitte Vollmar, Bernd J. Krause, Georg Lamprecht
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Molecular Metabolism
Subjects:
Glucagon-like peptide-2
Bile acid metabolome
cyp8b1
SeHCAT
Short bowel syndrome
Ileocecal resection
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000286
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