Age differences in immunity to human seasonal coronaviruses and the immunogenicity of ChAdOx1 nCoV-19 (AZD1222)Research in context

Age differences in immunity to human seasonal coronaviruses and the immunogenicity of ChAdOx1 nCoV-19 (AZD1222)Research in context

Summary: Background: ChAdOx1 nCoV-19 (AZD1222) vaccine was widely deployed to protect against severe COVID-19 in adults, but the relationship between pre-existing immunity to human seasonal coronaviruses (HCoVs) and vaccine-induced SARS-CoV-2 (SCoV2) response across age groups remains unclear. Meth...

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Main Authors: Sandra Belij-Rammerstorfer, Emma Sheehan, Grace Li, Sagida Bibi, Daniel Wright, Merryn Voysey, Cameron Bissett, Ninisha Barman, Susana Camara, Audrey Au Yong, Sue Ann Costa Clemens, Mae Harris, Amy Flaxman, Jordan Barrett, Khiyam Hussain, Gareth Lipunga, Robert H. Shaw, Holly Smith, Stanley Cheruiyot, John N. Gitonga, Daisy Mugo, Henry K. Karanja, George M. Warimwe, Mainga M. Hamaluba, Lily Y. Weckx, Andrew J. Pollard, Teresa Lambe
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
ChAdOx1 nCoV-19
Age groups
Human seasonal coronaviruses
FcγR
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002919
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