The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

Exogenously administered glucocorticoids enhance eosinophil and neutrophil granulocyte production from murine bone-marrow. A hematological response dependent on endogenous glucocorticoids underlies bone-marrow eosinophilia induced by trauma or allergic sensitization/challenge. We detected a defect...

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Main Authors: Pedro Xavier-Elsas, Cássio Luiz Coutinho Almeida da Silva, Bruno Marques Vieira, Daniela Masid-de-Brito, Túlio Queto, Bianca de Luca, Thiago Soares de Souza Vieira, Maria Ignez C. Gaspar-Elsas
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2015/495430
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http://dx.doi.org/10.1155/2015/495430

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