MMP14 as a central mediator of TGF-β1−induced extracellular matrix remodeling in graves’ orbitopathy

MMP14 as a central mediator of TGF-β1−induced extracellular matrix remodeling in graves’ orbitopathy

BackgroundGraves’ orbitopathy (GO) is an autoimmune orbital disorder characterized by chronic inflammation and aberrant extracellular matrix (ECM) remodeling, leading to progressive fibrosis. Recent studies implicate matrix metalloproteinase−14 (MMP14) in ECM degradation and tissue remodeling, yet i...

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Bibliographic Details
Main Authors: Xing Wang, Jing Lu, Yuxia He, Qinxin Shu, Yuxin Lin, Wenqi Su, Peng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
graves’ orbitopathy (GO)
matrix metalloproteinase 14 (MMP14)
fibrosis
extracellular matrix
tissue remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1623842/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1623842/full

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