Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors

Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors

Abstract Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are rare, aggressive mesenchymal neoplasms with high recurrence and metastasis rates. Here, we perform a comprehensive multi-omics analysis of 189 cases of CNS SFTs integrating 94 whole genome sequencing, 88 transcriptomics,...

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Main Authors: Chenhui Zhao, Xueyan Hu, Xiudong Guan, Xiaojun Fu, Tingting Wang, Mengyuan Li, Xinze Liu, Jiarui Zhao, Di Wu, Fan Zhang, Jiaying Fu, Jiang Li, Tieqiang Zhang, Xiaochun Jiang, Changxiang Yan, Wang Jia, Ence Yang, Jian Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63039-4
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https://doi.org/10.1038/s41467-025-63039-4

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