ALS-associated TDP-43 aggregates drive innate and adaptive immune cell activation

ALS-associated TDP-43 aggregates drive innate and adaptive immune cell activation

Summary: Amyotrophic lateral sclerosis (ALS) is the most common and fatal motor neuron disease. Approximately 90% of ALS patients exhibit pathology of the master RNA regulator, transactive response DNA binding protein (TDP-43). Despite the prevalence TDP-43 pathology in ALS motor neurons, recent fin...

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Main Authors: Baggio A. Evangelista, Joey V. Ragusa, Kyle Pellegrino, Yijia Wu, Ivana Yoseli Quiroga-Barber, Shannon R. Cahalan, Omeed K. Arooji, Jillann A. Madren, Sally Schroeter, Joe Cozzarin, Ling Xie, Xian Chen, Kristen K. White, J. Ashley Ezzell, Marie A. Iannone, Sarah Cohen, Douglas H. Phanstiel, Rick B. Meeker, Todd J. Cohen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Neuroscience
Immunity
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009095
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http://www.sciencedirect.com/science/article/pii/S2589004225009095

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