Design, synthesis and in Silico evaluation of novel thiazol-4(5H)-one-appended isatin–triazole hybrids with protective effects against inflammation, oxidative stress, and lymphocyte infiltration in a type 1 diabetic rat model

Design, synthesis and in Silico evaluation of novel thiazol-4(5H)-one-appended isatin–triazole hybrids with protective effects against inflammation, oxidative stress, and lymphocyte infiltration in a type 1 diabetic rat model

Pancreatic inflammation plays a critical role in the development and progression of type 1 diabetes (T1D). In this study, a series of novel 1,2,3-triazole-linked isatin-thiazol-4(5H)-one hybrids were rationally designed and synthesized via a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) rea...

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Main Authors: Walaa I. El-Sofany, Amani Toumi, Salman Latif, Ismail Daoud, Mourad Jridi, Asmaa F. Kassem, Kaseb D. Alanazi, Munirah S.O. Alhar, Abdalla Abdelwahab, Violeta Jevtovic, Sarra Boudriga
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Chemical Physics Impact
Subjects:
Type 1 diabetes
Inflammation
Oxidative stress
1,2,3-triazole
Hybrid
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022425001161
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