Imaging Striatal Microglial Activation in Patients with Parkinson's Disease.
This study investigated whether the second-generation translocator protein 18kDa (TSPO) radioligand, [18F]-FEPPA, could be used in neurodegenerative parkinsonian disorders as a biomarker for detecting neuroinflammation in the striatum. Neuroinflammation has been implicated as a potential mechanism f...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138721&type=printable |
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| author | Yuko Koshimori Ji-Hyun Ko Romina Mizrahi Pablo Rusjan Rostom Mabrouk Mark F Jacobs Leigh Christopher Clement Hamani Anthony E Lang Alan A Wilson Sylvain Houle Antonio P Strafella |
| author_facet | Yuko Koshimori Ji-Hyun Ko Romina Mizrahi Pablo Rusjan Rostom Mabrouk Mark F Jacobs Leigh Christopher Clement Hamani Anthony E Lang Alan A Wilson Sylvain Houle Antonio P Strafella |
| author_sort | Yuko Koshimori |
| collection | DOAJ |
| description | This study investigated whether the second-generation translocator protein 18kDa (TSPO) radioligand, [18F]-FEPPA, could be used in neurodegenerative parkinsonian disorders as a biomarker for detecting neuroinflammation in the striatum. Neuroinflammation has been implicated as a potential mechanism for the progression of Parkinson's disease (PD). Positron Emission Tomography (PET) radioligand targeting for TSPO allows for the quantification of neuroinflammation in vivo. Based on genotype of the rs6791 polymorphism in the TSPO gene, 16 mixed-affinity binders (MABs) (8 PD and age-matched 8 healthy controls (HCs)), 16 high-affinity binders (HABs) (8 PD and age-matched 8 HCs) and 4 low-affinity binders (LABs) (3 PD and 1 HCs) were identified. Total distribution volume (VT) values in the striatum were derived from a two-tissue compartment model with arterial plasma as an input function. There was a significant main effect of genotype on [18F]-FEPPA VT values in the caudate nucleus (p = 0.001) and putamen (p < 0.001), but no main effect of disease or disease x genotype interaction in either ROI. In the HAB group, the percentage difference between PD and HC was 16% in both caudate nucleus and putamen; in the MAB group, it was -8% and 3%, respectively. While this PET study showed no evidence of increased striatal TSPO expression in PD patients, the current findings provide some insights on the possible interactions between rs6791 polymorphism and neuroinflammation in PD. |
| format | Article |
| id | doaj-art-71fb6f322fac47f39473fe5d0818ecf0 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-71fb6f322fac47f39473fe5d0818ecf02025-08-20T02:22:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013872110.1371/journal.pone.0138721Imaging Striatal Microglial Activation in Patients with Parkinson's Disease.Yuko KoshimoriJi-Hyun KoRomina MizrahiPablo RusjanRostom MabroukMark F JacobsLeigh ChristopherClement HamaniAnthony E LangAlan A WilsonSylvain HouleAntonio P StrafellaThis study investigated whether the second-generation translocator protein 18kDa (TSPO) radioligand, [18F]-FEPPA, could be used in neurodegenerative parkinsonian disorders as a biomarker for detecting neuroinflammation in the striatum. Neuroinflammation has been implicated as a potential mechanism for the progression of Parkinson's disease (PD). Positron Emission Tomography (PET) radioligand targeting for TSPO allows for the quantification of neuroinflammation in vivo. Based on genotype of the rs6791 polymorphism in the TSPO gene, 16 mixed-affinity binders (MABs) (8 PD and age-matched 8 healthy controls (HCs)), 16 high-affinity binders (HABs) (8 PD and age-matched 8 HCs) and 4 low-affinity binders (LABs) (3 PD and 1 HCs) were identified. Total distribution volume (VT) values in the striatum were derived from a two-tissue compartment model with arterial plasma as an input function. There was a significant main effect of genotype on [18F]-FEPPA VT values in the caudate nucleus (p = 0.001) and putamen (p < 0.001), but no main effect of disease or disease x genotype interaction in either ROI. In the HAB group, the percentage difference between PD and HC was 16% in both caudate nucleus and putamen; in the MAB group, it was -8% and 3%, respectively. While this PET study showed no evidence of increased striatal TSPO expression in PD patients, the current findings provide some insights on the possible interactions between rs6791 polymorphism and neuroinflammation in PD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138721&type=printable |
| spellingShingle | Yuko Koshimori Ji-Hyun Ko Romina Mizrahi Pablo Rusjan Rostom Mabrouk Mark F Jacobs Leigh Christopher Clement Hamani Anthony E Lang Alan A Wilson Sylvain Houle Antonio P Strafella Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. PLoS ONE |
| title | Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. |
| title_full | Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. |
| title_fullStr | Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. |
| title_full_unstemmed | Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. |
| title_short | Imaging Striatal Microglial Activation in Patients with Parkinson's Disease. |
| title_sort | imaging striatal microglial activation in patients with parkinson s disease |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0138721&type=printable |
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