Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines

Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines

Abstract Personalized cancer vaccines (PCVs) largely leverage neoantigens arising from somatic mutations, limiting their application to patients with relatively high tumor mutational burden (TMB). This underscores the need for alternative antigens to design PCVs for low TMB cancers. To this end, we...

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Main Authors: Christian Garde, Michail A. Pavlidis, Pablo Garces, Emma J. Lange, Sri H. Ramarathinam, Mateo Sokač, Kirti Pandey, Pouya Faridi, Johanne Ahrenfeldt, Shanzou Chung, Stine Friis, Daniela Kleine-Kohlbrecher, Nicolai J. Birkbak, Jens V. Kringelum, Birgitte Rønø, Anthony W. Purcell, Thomas Trolle
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01107-y
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https://doi.org/10.1038/s41541-025-01107-y

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