Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Abstract Multimorbidity is common in older adults. However, whether multimorbidity accelerates brain beta-amyloid (Aβ) deposition, the molecular driver of Alzheimer’s disease (AD), in humans remains largely unknown. In this study, we selected 435 brain Aβ-positive participants with available longitu...

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Main Authors: Xian-Le Bu, Wei Zhu, Qing-Hua Wang, Zhuo-Ting Liu, Yun-Yu Bao, Yu-Di Bai, Jiang-Hui Li, Zhi-Hao Liu, Jia-Ling Zhao, Yang Xiang, Wang-Sheng Jin, Jun Wang, Xia Lei, Yan-Jiang Wang, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60748-8
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https://doi.org/10.1038/s41467-025-60748-8

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