The Role of Bacteria and Pattern Recognition Receptors in GvHD
Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2010/814326 |
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| author | E. Holler K. Landfried J. Meier M. Hausmann G. Rogler |
| author_facet | E. Holler K. Landfried J. Meier M. Hausmann G. Rogler |
| author_sort | E. Holler |
| collection | DOAJ |
| description | Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. With the detailed description of pathogen-associated molecular patterns and pathogen recognition receptors single nucleotide polymorphisms of TLRs and especially NOD2 have been identified as potential risk factors of GvHD and transplant related complications thus further supporting the crucial role of innate immunity in SCT, related complications. Gastrointestinal decontamination and neutralization of endotoxin have been used to interfere with this early axis of activation with some success but more specific approaches of modulation of innate immunity are needed for further improvement of clinical outcome. |
| format | Article |
| id | doaj-art-71e72c05b9134d00baa162a799cde56c |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-71e72c05b9134d00baa162a799cde56c2025-02-03T01:26:06ZengWileyInternational Journal of Inflammation2042-00992010-01-01201010.4061/2010/814326814326The Role of Bacteria and Pattern Recognition Receptors in GvHDE. Holler0K. Landfried1J. Meier2M. Hausmann3G. Rogler4Department of Haematology/Oncology, University of Regensburg, 93042 Regensburg, GermanyDepartment of Haematology/Oncology, University of Regensburg, 93042 Regensburg, GermanyDepartment of Cranio-Maxillofacial Surgery, University of Regensburg, 93042 Regensburg, GermanyDivision of Gastroenterology and Hepatology, University of Zurich, 8091 Zurich, SwitzerlandDivision of Gastroenterology and Hepatology, University of Zurich, 8091 Zurich, SwitzerlandGraft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. With the detailed description of pathogen-associated molecular patterns and pathogen recognition receptors single nucleotide polymorphisms of TLRs and especially NOD2 have been identified as potential risk factors of GvHD and transplant related complications thus further supporting the crucial role of innate immunity in SCT, related complications. Gastrointestinal decontamination and neutralization of endotoxin have been used to interfere with this early axis of activation with some success but more specific approaches of modulation of innate immunity are needed for further improvement of clinical outcome.http://dx.doi.org/10.4061/2010/814326 |
| spellingShingle | E. Holler K. Landfried J. Meier M. Hausmann G. Rogler The Role of Bacteria and Pattern Recognition Receptors in GvHD International Journal of Inflammation |
| title | The Role of Bacteria and Pattern Recognition Receptors in GvHD |
| title_full | The Role of Bacteria and Pattern Recognition Receptors in GvHD |
| title_fullStr | The Role of Bacteria and Pattern Recognition Receptors in GvHD |
| title_full_unstemmed | The Role of Bacteria and Pattern Recognition Receptors in GvHD |
| title_short | The Role of Bacteria and Pattern Recognition Receptors in GvHD |
| title_sort | role of bacteria and pattern recognition receptors in gvhd |
| url | http://dx.doi.org/10.4061/2010/814326 |
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