Insights into antibacterial design: Computational modeling of eugenol derivatives targeting DNA gyrase

Insights into antibacterial design: Computational modeling of eugenol derivatives targeting DNA gyrase

The rise of antibiotic resistance underscores the urgent need for novel antibacterial agents. DNA gyrase, an essential enzyme involved in bacterial DNA replication, is a promising target for antibacterial therapy. Computational approaches offer a cost-effective means to design and screen potential i...

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Bibliographic Details
Main Authors: Heba S. Elsewedy, Sultan Alshehri, Adeola T. Kola-Mustapha, Shaymaa M. Genedy, Khuzama M. Siddiq, Bushra Y. Asiri, Rehab A. Alshammari, Heba Mohammed Refat M. Selim, Oluwakorede J. Adedeji, George Oche Ambrose
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
Eugenol
DNA gyrase
Antibacterial
Molecular docking
Natural products
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024154254
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