Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase
Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated th...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8102170 |
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| author | Giovanna Traina Samuela Cataldi Paola Siccu Elisabetta Loreti Ivana Ferri Angelo Sidoni Michela Codini Chiara Gizzi Marzia Sichetti Francesco Saverio Ambesi-Impiombato Tommaso Beccari Francesco Curcio Elisabetta Albi |
| author_facet | Giovanna Traina Samuela Cataldi Paola Siccu Elisabetta Loreti Ivana Ferri Angelo Sidoni Michela Codini Chiara Gizzi Marzia Sichetti Francesco Saverio Ambesi-Impiombato Tommaso Beccari Francesco Curcio Elisabetta Albi |
| author_sort | Giovanna Traina |
| collection | DOAJ |
| description | Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroid microstructure and the possibility that molecules involved in thyroid function might be associated with structural changes. Results from this study indicate changes in the height of the thyrocytes and in the amplitude of interfollicular spaces, anomalous expression/localization of thyrotropin, thyrotropin receptor, and thyroglobulin aging. Thyrotropin and thyrotropin receptor are upregulated and are distributed inside the colloid while thyroglobulin fills the interfollicular spaces. In an approach aimed at defining the behavior of molecules that change in different physiopathological conditions of thyroid, such as galectin-3 and sphingomyelinase, we then wondered what was their behavior in the thyroid gland in aging. Importantly, in comparison with the thyroid of young animals, we have found a higher expression of galectin-3 and a delocalization of neutral sphingomyelinase in the thyroid of old animals. A possible relationship between galectin-3, neutral sphingomyelinase, and aging has been discussed. |
| format | Article |
| id | doaj-art-71caa2fcae3f407baedcb0bef0f20d1a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-71caa2fcae3f407baedcb0bef0f20d1a2025-02-03T01:21:17ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/81021708102170Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and SphingomyelinaseGiovanna Traina0Samuela Cataldi1Paola Siccu2Elisabetta Loreti3Ivana Ferri4Angelo Sidoni5Michela Codini6Chiara Gizzi7Marzia Sichetti8Francesco Saverio Ambesi-Impiombato9Tommaso Beccari10Francesco Curcio11Elisabetta Albi12Department of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyDivision of Anatomic Pathology and Histology, Department of Experimental Medicine, School of Medicine and Surgery, University of Perugia, Perugia, ItalyDivision of Anatomic Pathology and Histology, Department of Experimental Medicine, School of Medicine and Surgery, University of Perugia, Perugia, ItalyDivision of Anatomic Pathology and Histology, Department of Experimental Medicine, School of Medicine and Surgery, University of Perugia, Perugia, ItalyDivision of Anatomic Pathology and Histology, Department of Experimental Medicine, School of Medicine and Surgery, University of Perugia, Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyDepartment of Medica Area, University of Udine, P.le M. Kolbe 4, 33100 Udine, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyDepartment of Medica Area, University of Udine, P.le M. Kolbe 4, 33100 Udine, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, ItalyPrevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroid microstructure and the possibility that molecules involved in thyroid function might be associated with structural changes. Results from this study indicate changes in the height of the thyrocytes and in the amplitude of interfollicular spaces, anomalous expression/localization of thyrotropin, thyrotropin receptor, and thyroglobulin aging. Thyrotropin and thyrotropin receptor are upregulated and are distributed inside the colloid while thyroglobulin fills the interfollicular spaces. In an approach aimed at defining the behavior of molecules that change in different physiopathological conditions of thyroid, such as galectin-3 and sphingomyelinase, we then wondered what was their behavior in the thyroid gland in aging. Importantly, in comparison with the thyroid of young animals, we have found a higher expression of galectin-3 and a delocalization of neutral sphingomyelinase in the thyroid of old animals. A possible relationship between galectin-3, neutral sphingomyelinase, and aging has been discussed.http://dx.doi.org/10.1155/2017/8102170 |
| spellingShingle | Giovanna Traina Samuela Cataldi Paola Siccu Elisabetta Loreti Ivana Ferri Angelo Sidoni Michela Codini Chiara Gizzi Marzia Sichetti Francesco Saverio Ambesi-Impiombato Tommaso Beccari Francesco Curcio Elisabetta Albi Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase Mediators of Inflammation |
| title | Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase |
| title_full | Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase |
| title_fullStr | Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase |
| title_full_unstemmed | Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase |
| title_short | Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase |
| title_sort | mouse thyroid gland changes in aging implication of galectin 3 and sphingomyelinase |
| url | http://dx.doi.org/10.1155/2017/8102170 |
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