Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer
Background: Breast cancer treatments often have negative effects on fertility, which pose challenges among patients who want to be parents in the future. This study aimed to examine the efficacy of oocyte cryopreservation, embryo cryopreservation, and ovarian tissue cryopreservation in patients with...
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Elsevier
2025-02-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664624003565 |
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| author | Chao-Ying Chen Yu-Chiao Yi Hwa-Fen Guu Ya-Fang Chen Hsiao-Fan Kung Jui-Chun Chang Li-Yu Chen Chih-Chiang Hung Ming-Jer Chen |
| author_facet | Chao-Ying Chen Yu-Chiao Yi Hwa-Fen Guu Ya-Fang Chen Hsiao-Fan Kung Jui-Chun Chang Li-Yu Chen Chih-Chiang Hung Ming-Jer Chen |
| author_sort | Chao-Ying Chen |
| collection | DOAJ |
| description | Background: Breast cancer treatments often have negative effects on fertility, which pose challenges among patients who want to be parents in the future. This study aimed to examine the efficacy of oocyte cryopreservation, embryo cryopreservation, and ovarian tissue cryopreservation in patients with breast cancer. Methods: This retrospective review evaluated 42 patients with breast cancer who underwent fertility preservation at our center from January 2012 to December 2022. This review encompassed the demographic characteristics of the patients, cancer stages, treatment details, and types of fertility preservation procedures and their outcomes. Results: The average age at disease diagnosis was 33.4 years. Approximately 90.4% of patients presented with early-stage cancer (≤2). Of 42 patients, 26 underwent oocyte cryopreservation; 17, embryo cryopreservation; and 2, ovarian tissue cryopreservation. Further, three patients received mixed treatment. The overall live birth rate was 63.2%. There are more live births in embryo cryopreservation group. The successful pregnancy group was significantly younger and had a remarkably higher quantity of preserved oocytes/embryos than the nonsuccessful pregnancy group. The oocyte and embryo utilization rates in cryopreservation were 7.69% and 52.94%, respectively. These findings underscored the importance of prompt, informed discussions about fertility preservation options. Conclusion: Fertility preservation in patients with breast cancer have promising reproductive outcomes, with embryo cryopreservation being particularly effective. Prompt counseling and individualized fertility preservation strategies are important for improving the likelihood of posttreatment pregnancy. Nevertheless, future research on the long-term psychological and emotional effects of different fertility preservation methods must be performed. |
| format | Article |
| id | doaj-art-71c9c7b8ff774d5fad61b4e8feba6689 |
| institution | Kabale University |
| issn | 0929-6646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj-art-71c9c7b8ff774d5fad61b4e8feba66892025-02-02T05:26:48ZengElsevierJournal of the Formosan Medical Association0929-66462025-02-011242112117Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancerChao-Ying Chen0Yu-Chiao Yi1Hwa-Fen Guu2Ya-Fang Chen3Hsiao-Fan Kung4Jui-Chun Chang5Li-Yu Chen6Chih-Chiang Hung7Ming-Jer Chen8Department of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, TaiwanDepartment of Surgery, Division of Breast Surgery, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Corresponding author. Department of Obstetrics and Gynecology and Women's Health, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Xitun District, Taichung City, 407, Taiwan.Background: Breast cancer treatments often have negative effects on fertility, which pose challenges among patients who want to be parents in the future. This study aimed to examine the efficacy of oocyte cryopreservation, embryo cryopreservation, and ovarian tissue cryopreservation in patients with breast cancer. Methods: This retrospective review evaluated 42 patients with breast cancer who underwent fertility preservation at our center from January 2012 to December 2022. This review encompassed the demographic characteristics of the patients, cancer stages, treatment details, and types of fertility preservation procedures and their outcomes. Results: The average age at disease diagnosis was 33.4 years. Approximately 90.4% of patients presented with early-stage cancer (≤2). Of 42 patients, 26 underwent oocyte cryopreservation; 17, embryo cryopreservation; and 2, ovarian tissue cryopreservation. Further, three patients received mixed treatment. The overall live birth rate was 63.2%. There are more live births in embryo cryopreservation group. The successful pregnancy group was significantly younger and had a remarkably higher quantity of preserved oocytes/embryos than the nonsuccessful pregnancy group. The oocyte and embryo utilization rates in cryopreservation were 7.69% and 52.94%, respectively. These findings underscored the importance of prompt, informed discussions about fertility preservation options. Conclusion: Fertility preservation in patients with breast cancer have promising reproductive outcomes, with embryo cryopreservation being particularly effective. Prompt counseling and individualized fertility preservation strategies are important for improving the likelihood of posttreatment pregnancy. Nevertheless, future research on the long-term psychological and emotional effects of different fertility preservation methods must be performed.http://www.sciencedirect.com/science/article/pii/S0929664624003565Breast cancerFertility preservationOocyte cryopreservationEmbryo cryopreservationCancer treatmentReproductive outcomes |
| spellingShingle | Chao-Ying Chen Yu-Chiao Yi Hwa-Fen Guu Ya-Fang Chen Hsiao-Fan Kung Jui-Chun Chang Li-Yu Chen Chih-Chiang Hung Ming-Jer Chen Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer Journal of the Formosan Medical Association Breast cancer Fertility preservation Oocyte cryopreservation Embryo cryopreservation Cancer treatment Reproductive outcomes |
| title | Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer |
| title_full | Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer |
| title_fullStr | Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer |
| title_full_unstemmed | Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer |
| title_short | Pathways to motherhood: A single-center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer |
| title_sort | pathways to motherhood a single center retrospective study on fertility preservation and reproductive outcomes in patients with breast cancer |
| topic | Breast cancer Fertility preservation Oocyte cryopreservation Embryo cryopreservation Cancer treatment Reproductive outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S0929664624003565 |
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