Reducing PDK4 level constitutes a pivotal mechanism for glucocorticoids to impede osteoblastic differentiation through the enhancement of ferroptosis in mesenchymal stem cells

Reducing PDK4 level constitutes a pivotal mechanism for glucocorticoids to impede osteoblastic differentiation through the enhancement of ferroptosis in mesenchymal stem cells

Abstract Background This study mainly explores the possible role and mechanism of pyruvate dehydrogenase kinase 4 (PDK4) in the onset and development of Glucocorticoid-induced osteoporosis (GIOP), and seeks potential targets for the treatment of GIOP. Methods Mesenchymal stem cells (MSCs) were treat...

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Main Authors: Yue Jiang, Ai-Hua Ye, Wen-Ge He, Lu Liu, Xiang Gao, Hang Liu, Wen-Ting Liu, Fang-Lin Ye, Dong-Mei He, Jun-Yi Liao, Jing Wang, Bai-Cheng He
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Glucocorticoid-induced osteoporosis (GIOP)
Dexamethasone
Osteogenic differentiation
Pyruvate dehydrogenase kinase 4
Ferroptosis
Online Access:https://doi.org/10.1186/s13287-025-04186-9
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https://doi.org/10.1186/s13287-025-04186-9

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