Downregulation of IRF7-mediated type-I interferon response by LmCen –/– parasites is necessary for protective immunity

Downregulation of IRF7-mediated type-I interferon response by LmCen –/– parasites is necessary for protective immunity

Abstract Leishmaniasis is a tropical disease caused by Leishmania parasites and currently has no licensed vaccines. We developed a dermotropic Leishmania major centrin gene-deleted strain (LmCen –/–) as a live attenuated vaccine. Recent studies have shown that type I interferons (IFNs) play importan...

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Main Authors: Telly Sepahpour, Jalal Alshaweesh, Nazli Azodi, Komudi Singh, Derek D. C. Ireland, Farzaneh Valanezhad, Risa Nakamura, Abhay R. Satoskar, Ranadhir Dey, Shinjiro Hamano, Hira L. Nakhasi, Sreenivas Gannavaram
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-01032-6
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https://doi.org/10.1038/s41541-024-01032-6

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