Complex interplay between type 2 diabetes mellitus and pancreatic cancer: insights from observational and mendelian randomization analyses

Complex interplay between type 2 diabetes mellitus and pancreatic cancer: insights from observational and mendelian randomization analyses

Abstract Background To investigate the causal relationship between type 2 diabetes mellitus (T2DM), pancreatic cancer (PC) risk and identify the mediating effects of various risk factors on that relationship. Methods 581 PC patients and 582 healthy controls who visited our center from January 2013 t...

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Bibliographic Details
Main Authors: Yuxin Wang, Lu Xie, Ye Gu, Hangbin Jin, Jianfeng Yang, Qiang Liu, Xiaofeng Zhang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
Type 2 diabetes mellitus
Mendelian randomization
Causal mediation analysis
Risk factors
Online Access:https://doi.org/10.1186/s12885-025-13976-6
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https://doi.org/10.1186/s12885-025-13976-6

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