ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells

ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells

Abstract Identifying novel targets for molecular radiosensitization is critical for improving the efficacy of colorectal cancer (CRC) radiotherapy. Alpha-thalassemia/mental retardation X-linked (ATRX), a member of the SWI/SNF-like chromatin remodeling protein family, functions in the maintenance of...

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Bibliographic Details
Main Authors: Lijing Qin, Geng Tang, Ruirui Gui, Yanming Yang, Li Wang, Weiqiang Xu, Hongyuan Tian, Lei Yu, Xiangshan Yang, Zhicheng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
ATRX
Radiosensitivity
DNA damage response
Daxx/MDM2/p53 pathway
Colorectal cancer
Online Access:https://doi.org/10.1038/s41598-024-85085-6
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https://doi.org/10.1038/s41598-024-85085-6

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