Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy

Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy

Abstract Background Diabetic cardiomyopathy (DCM) is a complex condition linked to diabetes, characterized by cardiac and vascular dysfunction, frequently concomitant with heart failure with preserved ejection fraction. The extracellular matrix glycoprotein Tenascin-C (TNC) has been found to be upre...

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Main Authors: Zsuzsanna Arnold, Christopher Dostal, Petra Lujza Szabó, Ibrahim Aykac, Ana Isabel Antunes Goncalves, Silva Laura Sousa, Simge Baydar, Heidi Budde, Barnabás Váradi, György L. Nadasy, Mária Szekeres, Camilla Hage, Lars H. Lund, Sarah Costantino, Dietmar Abraham, Karin Zins, Seth Hallström, Martin Bilban, Bence Ágg, Nazha Hamdani, Péter Ferdinandy, Francesco Paneni, Attila Kiss, Bruno K. Podesser
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cardiovascular Diabetology
Subjects:
Tenascin-C
Diabetic cardiomyopathy
Heart failure pathophysiology
Fibrosis
Inflammation
Online Access:https://doi.org/10.1186/s12933-025-02780-y
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https://doi.org/10.1186/s12933-025-02780-y

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