Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors

Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors

Abstract Most new cancer diagnoses occur in patients over the age of 65. The composition and function of the immune system changes with age, but how the aged immune system affects responses to immune checkpoint inhibitor (ICI) cancer therapies remains incompletely understood. Here, using multiplex c...

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Main Authors: Chester Kao, Soren Charmsaz, Hua-Ling Tsai, Khaled Aziz, Daniel H. Shu, Kabeer Munjal, Ervin Griffin, James M. Leatherman, Evan J. Lipson, Yasser Ged, Jeannie Hoffman-Censits, Howard L. Li, Elsa Hallab, Madelena Brancati, Mari Nakazawa, Stephanie Alden, Christopher Thoburn, Nicole E. Gross, Alexei G. Hernandez, Erin M. Coyne, Emma Kartalia, Marina Baretti, Elizabeth M. Jaffee, Sanjay Bansal, Laura Tang, G. Scott Chandler, Rajat Mohindra, Won Jin Ho, Mark Yarchoan, Daniel J. Zabransky
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58512-z
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https://doi.org/10.1038/s41467-025-58512-z

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