Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein, a highly efficient strategy was developed for discovering the Mpro inactivators from crude plant extract integrating target-based biochemical assay and chemoproteomic...

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Bibliographic Details
Main Authors: Guanghao Zhu, Yani Zhang, Shenglan Qi, Jianrong Xu, Yuan Xiong, Zhaoqin Zhang, Xixiang Chen, Yuanyuan Xie, Xiaoqing Guan, Weidong Zhang, Wei Liu, Guangbo Ge
Format: Article
Language:English
Published: Tsinghua University Press 2025-05-01
Series:Food Science and Human Wellness
Subjects:
main proteases (mpro)
plant extract
pu-erh tea
global chemical analysis
cysteine-modification profiling
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2024.9250120
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https://www.sciopen.com/article/10.26599/FSHW.2024.9250120

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