Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Abstract Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies in various organ-specific cells and bodily...

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Main Authors: Kirsten Broderick, Mohamed Taha Moutaoufik, Tatiana Saccon, Ramy Malty, Shahreen Amin, Sadhna Phanse, Thomson Patrick Joseph, Mara Zilocchi, Ali Hosseinnia, Zoe Istace, Maryam Hajikarimlou, Sakib Abrar, Jade Fisher, Raelynn Brassard, Ranawaka Perera, Anil Kumar, Hiroyuki Aoki, Matineh Rahmatbakhsh, Matthew Jessulat, Darwyn Kobasa, Frank Dehne, Bhanu Prasad, Alla Gagarinova, M. Joanne Lemieux, Alan Cochrane, Walid A. Houry, Khaled A. Aly, Ashkan Golshani, Mohan Babu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60949-1
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https://doi.org/10.1038/s41467-025-60949-1

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