Recombinant chimeric horsepox virus (TNX-801) is attenuated relative to vaccinia virus strains in both in vitro and in vivo models

Recombinant chimeric horsepox virus (TNX-801) is attenuated relative to vaccinia virus strains in both in vitro and in vivo models

ABSTRACT Recombinant chimeric horsepox virus (TNX-801) is a preclinical vaccine in development against mpox and smallpox. In this report, we investigated the potential phenotypic differences in in vitro and in vivo models between TNX-801 and older vaccinia virus (VACV)-based vaccine strains (VACV-Li...

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Main Authors: Stephanie V. Trefry, Mayanka Awasthi, Christy N. Raney, Amy L. Cregger, Chase A. Gonzales, Brittney L. Layton, Robert N. Enamorado, Nelson A. Martinez, Deborah S. Gohegan, Masoudeh Masoud-Bahnamiri, Jennifer Y. Cho, Dawn M. Myscofski, Tinoush Moulaei, Natasza E. Ziółkowska, Scott J. Goebel, Seth Lederman, Sina Bavari, Farooq Nasar
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mSphere
Subjects:
Orthopoxvirus
horsepox
vaccinia
immunocompromised mice
human primary cells
Online Access:https://journals.asm.org/doi/10.1128/msphere.00265-24
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https://journals.asm.org/doi/10.1128/msphere.00265-24

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