Differential regulation of brain microvessel transcriptome and brain metabolome by western and heart-healthy dietary patterns in Ossabaw pigs

Differential regulation of brain microvessel transcriptome and brain metabolome by western and heart-healthy dietary patterns in Ossabaw pigs

Abstract Diet is a potentially modifiable neurodegenerative disease risk factor. We studied the effects of a typical Western diet (WD; high in refined carbohydrates, cholesterol and saturated fat), relative to a heart-healthy diet (HHD; high in unrefined carbohydrates, polyunsaturated fat and fiber,...

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Main Authors: Gloria Solano-Aguilar, Gregory Matuszek, Nirupa R. Matthan, Alice H. Lichtenstein, Xuedi Wang, Sukla Lakshman, Kathryn Barger, Joseph F. Urban, Aleksey Molokin, Rachel E. Bennett, Bradley T. Hyman, Stefania Lamon-Fava
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Neuroinflammation
Brain microvessels
Transcriptomics
Metabolomics
Online Access:https://doi.org/10.1038/s41598-024-81321-1
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https://doi.org/10.1038/s41598-024-81321-1

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