Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance

Plaat1 deficiency reduces cardiac cardiolipin content and impairs exercise tolerance

Phospholipase A and acyltransferase 1 (PLAAT1) catalyzes O-transacylase, N-transacylase, and phospholipase A1/2 reactions. We have demonstrated that PLAAT1 has O-transacylase activity in vitro using phosphatidylcholine as an acyl donor and monolysocardiolipin (MLCL) as an acyl acceptor, generating c...

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Bibliographic Details
Main Authors: Ashkan Hashemi, Ming Rong Liu, John Z. Chan, Antonia N. Berdeklis, Alex D. Cocco, Michelle V. Tomczewski, Douglas Strathdee, Ken D. Stark, Robin E. Duncan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Lipid Research
Subjects:
cardiolipin
cell signaling
glycerophospholipids
phospholipids/metabolism
heart
knockout mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000823
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