Infertility and Adenomyosis
Classically, the diagnosis of adenomyosis has only been possible on a hysterectomy specimen, usually in women in their late fourth and fifth decades, and, therefore, evaluating any relationship with infertility was simply not possible. As a consequence, to this day, no epidemiologic data exists link...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/786132 |
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| author | Sebastiano Campo Vincenzo Campo Giuseppe Benagiano |
| author_facet | Sebastiano Campo Vincenzo Campo Giuseppe Benagiano |
| author_sort | Sebastiano Campo |
| collection | DOAJ |
| description | Classically, the diagnosis of adenomyosis has only been possible on a hysterectomy specimen, usually in women in their late fourth and fifth decades, and, therefore, evaluating any relationship with infertility was simply not possible. As a consequence, to this day, no epidemiologic data exists linking adenomyosis to a state of subfertility. Today, new imaging techniques have enabled a noninvasive diagnosis at a much earlier time and a number of single-case or small series reports have appeared showing that medical, surgical, or combined treatment can restore fertility in women with adenomyosis, an indirect proof of an association. At the functional level, several anomalies found in the so-called junctional zone, or inner myometrium, in adenomyosis patients have been shown to be associated with poor reproductive performance, mainly through perturbed uterine peristalsis. Additional evidence for an association comes from experimental data: in baboons, adenomyosis is associated with lifelong primary infertility, as well as to endometriosis. Finally, indirect proof comes from studies of the eutopic and ectopic endometrium in women with adenomyosis proving the existence of an altered endometrial function and receptivity. In conclusion, sufficient indirect proof exists linking adenomyosis to infertility to warrant systematic clinical studies. |
| format | Article |
| id | doaj-art-711cc13a0db4433aae15e4ef10836a53 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-711cc13a0db4433aae15e4ef10836a532025-02-03T01:11:15ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/786132786132Infertility and AdenomyosisSebastiano Campo0Vincenzo Campo1Giuseppe Benagiano2Institute of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Largo Agostino Gemelli, 00168 Roma, ItalyInstitute of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Largo Agostino Gemelli, 00168 Roma, ItalyInstitute of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Largo Agostino Gemelli, 00168 Roma, ItalyClassically, the diagnosis of adenomyosis has only been possible on a hysterectomy specimen, usually in women in their late fourth and fifth decades, and, therefore, evaluating any relationship with infertility was simply not possible. As a consequence, to this day, no epidemiologic data exists linking adenomyosis to a state of subfertility. Today, new imaging techniques have enabled a noninvasive diagnosis at a much earlier time and a number of single-case or small series reports have appeared showing that medical, surgical, or combined treatment can restore fertility in women with adenomyosis, an indirect proof of an association. At the functional level, several anomalies found in the so-called junctional zone, or inner myometrium, in adenomyosis patients have been shown to be associated with poor reproductive performance, mainly through perturbed uterine peristalsis. Additional evidence for an association comes from experimental data: in baboons, adenomyosis is associated with lifelong primary infertility, as well as to endometriosis. Finally, indirect proof comes from studies of the eutopic and ectopic endometrium in women with adenomyosis proving the existence of an altered endometrial function and receptivity. In conclusion, sufficient indirect proof exists linking adenomyosis to infertility to warrant systematic clinical studies.http://dx.doi.org/10.1155/2012/786132 |
| spellingShingle | Sebastiano Campo Vincenzo Campo Giuseppe Benagiano Infertility and Adenomyosis Obstetrics and Gynecology International |
| title | Infertility and Adenomyosis |
| title_full | Infertility and Adenomyosis |
| title_fullStr | Infertility and Adenomyosis |
| title_full_unstemmed | Infertility and Adenomyosis |
| title_short | Infertility and Adenomyosis |
| title_sort | infertility and adenomyosis |
| url | http://dx.doi.org/10.1155/2012/786132 |
| work_keys_str_mv | AT sebastianocampo infertilityandadenomyosis AT vincenzocampo infertilityandadenomyosis AT giuseppebenagiano infertilityandadenomyosis |