Short-term consumption of the modified standard American diet perturbed the metabolic balance and altered DNA damage in MMTV-PyMT transgenic mice

Short-term consumption of the modified standard American diet perturbed the metabolic balance and altered DNA damage in MMTV-PyMT transgenic mice

Abstract Background Risk factors for breast cancer include obesity and hyperglycemia, which are associated with poor survival. Previous studies have used high-fat diets (HFDs) or Western-style diets to model dietary influences on breast cancer progression. However, these diets do not reflect the ene...

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Main Authors: Arlet Hernandez, Alekhya Puppala, Jenna Hedlich-Dwyer, Nayonika Mukherjee, Guihua Zhai, Valeria L. Dal Zotto, Bohan Ning, Hua Guo, Ritu Aneja, Natalie R. Gassman
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Subjects:
Breast cancer
American diet
Adiposity
Oxidative stress
DNA damage
Foxm1
Online Access:https://doi.org/10.1186/s13058-025-02075-w
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https://doi.org/10.1186/s13058-025-02075-w

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